You running a Nvidia chipset board? If so its normal. (hot-swap) Of course you cant just unplug your OS drive. 
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NZXT Apollo
S75QB 750W
ZEROtherm FZ120
Phenom II 720BE (X4) 3.5GHZ.
Gigabyte GA MA790X UD4P
G Skill DDR2 1066 4GB.
MSI GTS 250
Seagate 7200.12 500GB.
Welcome to the show
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