It's all preference. Some programs will allow you to change install directory. However, I would keep OS and programs on same drive/partition.
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Motherboard - Gigabyte GA-EP45-UD3R
CPU - E8400
Memory - 2GB Corsair XMS2 (2x 1gb)
Graphics - ATI HD3870
Hard Drives - 2-500gb WD Caviar Black
DVD Drives - Lite-On
Power Supply - Rosewill RP600V2-S-SL 600W
22" Acer widescreen AL2216WBD
OS - Windows XP
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