Is that a programmable model wih software or a basic corded model? If it a basic corded model your mouse.sys file may have been corrupted somehow. With the XP installation disk in the cd drive close out the auto loaded installed and proceed to the Run prompt off of the Start menu. Type in "sfc /scannow" there and press either the enter key or the ok button if that will work. This will start up the system file checker utility that repairs and replaces any system files found damaged or missing.
You may have been hit with a spyware or trojan even a virus that is now revealing itself. This would be one other thing to look into if the sfc doesn't correct the problem. The last item to consider of course is the display drivers are in need of removal and updating. If it's not Windows related your display drivers could have been corrupted somehow.
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