First of all, CTRL + ALT + DLT and find out how many processes are running. I would say, conservativly, anything over 35 = noticable negative system performance. With that said, also download Spybot S & D, Adaware, Microsoft Antispyware, and spyware blaster. Update the definitions in all of those programs. Do you have an anti-virus program? If so, update the definitions in that as well. Restart your computer into safe mode and run all of those programs. If after that, you still have issues, defragment your harddrive, run scandisk, and using msconfig, limit your startup processes as much as you can. Hope this helps.
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