I have an SPDIF optical cable which I use along with the Optical input setting to get full, brilliant, digital Dolby Digital Surround Sound from DVDs... so that definately works.
When I use my sound card to up-mix a stereo signal from music CDs, or up-mix the the stereo signal from downloaded movies to 5.1, it projects the sound to all 6 channels quite effectively.
I'm not sure if thats what you were asking... there aren't any other programs that use it.
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