Depends. First, I assume we're talking about DDR3 RAM here, correct? Anyways... if you have unlocked the memory speed, no, it won't slow down. If you have the divider set to 1:1 (which usually gives the best performance, unless the memory clock is set significantly higher than that of the FSB), the rated speed of the RAM will be only half of the rated speed of the FSB e.g. running DDR3-1333 on a mobo that's got an FSB of 1066 would backclock it down to 533. However, since DDR3 RAM can clock so high, you'd better set the DRAM:FSB ratio to 2:1, or to unlock the memory speed altogether (if possible) to get all out of your RAM.