It should I think there might be a jumper setting that you have to change the video card though.
There's the switch on the back of the PSU to go between 120/240 volts. A few automatically switch(my old Coolermaster was suppose to) Laptops typically work with either as well.
No...
If you're going to get into video cards, there's nothing to be changed if you're using a basic monitor. If you plan to use TV-Out or some sort of capture card, the drivers will have a setting to change from NTSC(US) to PAL(UK)