Not really no. SLI and crossfire only recognize the memory on the primary card. Well, rather it only USES the memory on the primary. It might say your total is doubled, but its not actually being put to use. Although I think the scenario changes when you're running say, a PhysX card or something, can't be sure, haven't really read up on it too much. This is what I've established myself so far though. Hope it helps.