That is how most do it - OS + regularly used programs on the SSD, everything else, including frequently used programs that would not benefit from the faster load times of the SSD, on a conventional hard drive. How Tremor said is also a good idea to throw in there as well, partition the hard drives so you have programs + storage. That way if something screws up with one or more of the programs on the hard drive, you have the option to format that partition whilst still leaving the important stored data safe.
For storage though, you would not want RAID0, especially for projects. One drive dies and you lose the lot. RAID1 or RAID5 is what you would want then, as a drive can die but you still have the data there intact