how to deal with such error ?

such error appears when my friends's computer starts frequently.

the error is below:

Runtime error 21 at 00405DCD

i don't know how to let it not apppear ?

who can help me ?

thanks in advanced.
 
I found something like that:

"An error that occurs during the execution of a program. In contrast, compile-time errors occur while a program is being compiled. Runtime errors indicate bugs in the program or problems that the designers had anticipated but could do nothing about. For example, running out of memory will often cause a runtime error.
Note that runtime errors differ from bombs or crashes in that you can often recover gracefully from a runtime error.
Source(s):

http://runtime-errors.com/?ovmtc=content"

You can try to determine which program causes that error.
You said that it's on bootup. Check your startup items: Start > Run > type: msconfig > Startup tab. You can disable startup items there. And checking one by one find the one causing the problem.
Leave the c:\windows\system... and check the c:\program files first.

Is that happening in Safe Mode too?
 
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