Please do the following. If you can't get this to work in regular mode then you may have to try the msconfig safe mode option.
Download this version of Rkill and run it
http://download.bleepingcomputer.com/grinler/iExplore.exe
When rkill log appears then immediately run combofix. Do not reboot the system after running rkill or you will have to do it again. If you can't get anything to work, then either you are forced to format and reinstall windows or take your pc to a computer repair shop and have them remove the infections for you.
Download this version of Rkill and run it
http://download.bleepingcomputer.com/grinler/iExplore.exe
When rkill log appears then immediately run combofix. Do not reboot the system after running rkill or you will have to do it again. If you can't get anything to work, then either you are forced to format and reinstall windows or take your pc to a computer repair shop and have them remove the infections for you.