At one time with XP, it could have been beneficial. I mean with dial-up. But with anything Vista and above the TCP/IP stack is optimized enough to not bother. The only thing you might want to adjust if you use P2P is the half-open connection limit or if you run a server you can harden the TCP/IP stack with manual registry edits, but if I can remember now those too are set in Vista and above.
In summary, snake oil.
As before, what exactly are you trying to accomplish?
LAN tweaks are irrelevant for latency when you already achieve sub 1 ms response to your router.
Well will see, my wireless on this machine on win 10 often gets disrupted, will see if it happens again that often and see if the new settings of TCP Optimizer will help on that,if not i will just uninstall it,so far there is no harm to the machine.
Then it's a problem with your wireless (physical layer) that isn't related to TCP (transport layer). Just blindly doing things 'just cuz' never fixes any actual problems.
What router do you have currently?