I haven't got to water cooling setups or even air conditioned pc cases as of yet. But I do catch word on occasional problems when they are not setup correctly. Some have reported having wet cases when something let go. But that may have been some in a rush to throw it together. Others have reported spending a good night installing one to get everything in properly. But anything that contains water can see possible water leaks. It's kind of like having a leaky faucet where you thought you shut it off completely and then... ?