2x4gb or 4x2gb

does a memory set up of 2x 4gb or 4x2gb have any beneits from the other?

There won't be any (real) speed benefits. However, the 2x4gb configuration will give you (if you have 4 slots in your motherboard) room to upgrade in the future. The counter argument being 4x2gb is usually cheaper.

I would go with 2x4gb.
 
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