like you mean, cut sime stuff? Yes, i heard yuo could. and i'm actually planing on doing it, some poeple say it would work good with a high water pressur cutter. Seems great to me. So i guess with that, you could do stuff on the side panel. But if you mean in the back of the PC, their ain't much to do. unless you want to take out the metal peice (where the PCI, AGP, and PCi-e slots are) that would make a few holes.