well that sounds like it'll make it a bit difficult to plug things into the back of it, and if you don't have a laptop style cd drive (type that the cd click into the try) that might be a problem but other than that you shouldn't have any problems. Also as a note if you are running the computer while driving be prepared to replace hard drive(s) because the bumps you hit can damage them really easily. If you don't have it on while you're moving you should be fine.