Casino Popup Virus that nothing will Catch!!!!

My computer has been acting up and all these disturbing casino popups keep appearing even if I am not on the Internet... I have run Norton Antivirus, Adware, Spybot Search and Destroy and countless other programs... NOTHING!!!!
I have tried removing it during safe mode, but it still won't work... I have tried using "run" then typing different things to see what the problem is... NOTHING!!!!
I even called some computer people to see if they could fix it... They came out to my house and still couldn't fix it...
I am on the edge right now and looking for HELP!!!!
I was just wondering if someone else has had this problem and how to fix it...
:(
 
ive had spyware like this on several occasions. on some of them ive managed to narrow it down to a particular program, when i removed it, it came back with a different name.
sadly the only "solution" ive found is to back up my important stuff, format and reinstall... not much of a solution but it worked
 
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