no. sata is faster but a few bucks more. Honestly i bought a case a sata drive but don't see it as faster. it was a 200 gig sata. but a usb2 is only so fast. Others would know if it made a diffidence. i do incidental backups and walk away. come back and its done.
eSATA is different. If the drive you are looking at is eSATA make sure your computer supports it. If it's the drive interface (ie the enclosure is USB) then it doesn't matter, USB is slower than both.