on the new drive i assume you will reinstall the os meaning that most all the programs you currently have should still work as long as they dont reuquire some info stored on the orginal boot drive.
You may want to backup some data however, for example certain data for all my games on win 7 sotred on in the C: drive, my boot partition, but all my games are installed on D:, this data usually includes stuff like save games, skins and so forth, baiscally stuff you've added since installation so you may need to back that up if you want to keep it.
So you could end up with installed program working but none of your saved information.