Too be honest dude my computer that i had usetwo be on 24/7 running multiple programs and i had no problems with it now I use my laptop I tend to keep it running for over 24 hours when im on holiday it is turned on for around 1-2 weeks straight so long as the room temperature doesnt exceed 20 centigrade that would cause your system to run at like 40-50 if fan or radiator cooled there should not be a problem if i lived in the hot parts of africa for instants it would only get turned on for around 6 hours just check your computers temp every day and if it is not showing a silly core temp that exceeds 50-60 centigrade there will be no damage to any of the hardware inside your machine.