i would advise against it, the blocks for your rig would probably run somewhere near $270 probably close to another $200 to cool your motherboard(there isn't anything other than fullcover for it) a pump would be 60 dollars, radiators would probably be $120(two swiftech 360 rads) 6 yate loons would be 40 dollars, barbs+hose clamps would be $6 dollars per block/radiator, so that would somewhere around $700 when you get all set and done if you cooled your motherboard, and with the gtx 295, its fairly easy to screw up with the waterblock install(shorts) in which case you wouldn't have warrenty, and as long as you leak test, there isn't much chance of a leak, but i really wouldn't reccommend it anyway