You need to update the firmware on the flashdrive so it'll work with Vista (the U3 part anyway) but otherwise it should work in Vista just fine.
why would you do that?U3 is God!
it really isnt lol.. takes ages to load.. and when im going from classroom to classroom its inconvienient
I have the exact same flash drive with U3 uninstalled and it works perfectly with Vista. Try dumping your files to a computer and then completely reformatting the flash drive.