If you locate and remove the drivers and software for the first board(knowing which ones that is) a repair install if then needed would work with the same cpu, memory, expansion cards(video, sound), and of course the same drive. The differences in chipsets, onboard controllers, and if using onboard video/sound would be a problem more then swapping the board itself. While a major item it's still one single hardware change. The one thing that lack while the current copy of Windows will still run is a fresh detection of a new board substituted for the first.