If the motherboard has a PCI-Express x16 slot, the card will work fine. You will need to plug the monitor into it (obviously) and preferably disable the onboard video, as well as get drivers off the internet.
if its PCI-e and even x8 not 16, it will be fine, just has to be a full length slot to get the most out of the card, there is very little performance loss going from x16 to x8