No, thats what the slots are for, where else are you going to put it? I have got boards from back in 1995 and have had many cards in the slots and they all work fine. But like anything some slots do go out but it would not have anything to do with having a card in it, unless the card shorted out or something.but i were to install a video card, keep it there it wouldn't really effect it?
You mean because it's always pushing the slot's pins out? I'm sure it eventually would if you keep swapping stuff out of the slots.