As StrangleHold said, lower timings are better but you also have to look at RAM speed. If your timings choices are 5-5-5-15 @ 800MHz or 9-9-9-27 @ 2000MHz which is better? You have a lot more cycles you can burn without really noticing it on the 2000MHz
I agree, 4-4-4-12 on that memory with 2.1V stock already is pretty aggressive without really pumping up the voltage or lowering the mhz.