From what I've seen its really better that you dont use a "fix-it-all" registry cleaner. There are loads of programs like this that advertise "IT can clean the registry and make things faster!". What they don't tell you is that if it cleans wrong, you may have to reinstall the OS. If the registry needs to be cleaned, or repaired its usually because there are a few items which shouldnt be there as with malware, uninstalled program leftovers which are interfering with other programs, unwanted items, etc...
There are ways of scanning the registry and fixing what needs to be fixed, but to do it right takes a skilled, knowledgeable individual. I'd uninstall the program; or if you paid for it and just want to keep it, then just leave it alone.