Consider Pale Moon and the addon Noscript. If you use Noscript go into the options and allow base 2nd level domains to lessen the cumbersomeness. Consider Sandboxie which will launch your browser in a sandbox, i.e virtual environment where if a virus get through it will only reside in the sandbox and not touch your computer. [strike]PITA to add bookmarks in the sandbox though. You have to copy the website address, close the sandbox and relaunch your browser without the sandbox and paste the url and bookmark. This is due to the fact any changes made in the sandbox are not saved. So if you change something in the sandbox it won't stick.[/strike] You still need an anti-virus software to protect against outside sources like a USB stick.
Consider a virus like Al Pacino who plays the devil in the Devils Advocate. Where are viruses? EVERYWHERE!
https://www.youtube.com/watch?v=d6NHUleXHcU
I use a RAM drive on the laptop and I have noticed rouge crap like Adware end up in the temp files. It was more than likely a false positive though. The temp files are in RAM so it clears on computer shutdown.
To make bookmarks stick in Firefox or Pale Moon under Sandboxie see this and look at my screen shots.
http://www.sandboxie.com/?FirefoxTips