No, you can boot the machine and enter the boot menu to select your CD drive to boot from. Then put the OS setup disk in the drive and hit enter.
What OS are you intending to install? Vista or XP? If it is Vista or XP SP2 or later, you shouldn't need a driver disk on hand if you are installing to a SATA drive. If you only have an XP SP1 or earlier install disk, you will need to have a floppy drive and floppy with the SATA driver on hand. If you are installing to an IDE drive in any case, you will be fine.
What OS are you intending to install? Vista or XP? If it is Vista or XP SP2 or later, you shouldn't need a driver disk on hand if you are installing to a SATA drive. If you only have an XP SP1 or earlier install disk, you will need to have a floppy drive and floppy with the SATA driver on hand. If you are installing to an IDE drive in any case, you will be fine.