Thanks for the reply. I understand you have to have a sata port on the motherboard. Since the internal card readers come with slots for multiple cards, USB ports, and and eSATA port on them, they also hook up to both a USB and a SATA connector on the motherboard. What I am wondering is, that by hooking to that SATA connector on the motherboard, is that just for the eSATA port that is on the card reader, or does that also connect the card slots, thus giving them the SATA speed rather than the USB 2.0 which the other connector is used for.